INTERCEPT Blood System for Plasma



Viruses

The INTERCEPT Blood System for plasma has been shown to inactivate a variety of viruses.  Viruses shown to be inactivated are listed in Table 1.

Table 1: Inactivation Claims - Viruses

Viruses Tested Using the INTERCEPT Blood System for Plasma
Extent of Inactivation*
(log10 reduction) 
Enveloped Viruses  
HIV-1 (cell-associated)** >6.7
HIV-1 (cell-free) >6.8
HBV (strain MS-2) >4.5
HCV (strain Hutchison) >4.5
HTLV-I (Human T-cell Lymphotropic Virus)** ≥4.5
HTLV-II (Human T-cell Lymphotropic Virus)** >5.7
WNV (West Nile Virus) ≥6.8
SARS-CoV (Human Corona Virus) ≥5.5
BVDV (Bovine Viral Diarrhea Virus, model virus for human HCV) ≥6.0
DHBV (Duck Hepatitis B Virus, model virus for human HBV) 4.4 - 4.5
Chikunguyna virus ≥7.6
Influenza A H5N1 virus (Avian Influenza) >5.7
Non-Enveloped Viruses  
BTV (Bluetongue Virus) 5.1
Human Adenovirus-5 ≥6.9
Parvo (Parvovirus B19) 1.8

* “>” refers to inactivation below the limit of detection of the assay
“≥” refers to inactivation at or below the limit of detection of the assay
** intracellular inoculum

 

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