Inactivation

INTERCEPT is not approved for sale in the US and certain other countries.

Platelets & Plasma

Parasites

Plasmodium & Babesia
- P Grellier, J Benach, M Labaied, S Charneau, H Gil, G Monsalve, R Alfonso, L Sawyer, L Lin, M Steiert, K Dupuis. Photochemical Inactivation with Amotosalen and Long-Wavelength Ultraviolet Light of Plasmodium and Babesia in Platelet and Plasma Components. Transfusion 2008;48(8):1676-84.
  > View abstract
T. Cruzi
- Van Voorhis WC, Barrett LK, Eastman RT et al. Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV. Antimicrob Agents Chemother 2003;47(2):475-9.
  > View abstract

Viruses

CMV
- Roback JD, Conlan M, Drew WL et al. The role of photochemical treatment with amotosalen and UVA light in the prevention of transfusion-transmitted cytomegalovirus infections. Transfus Med Rev 2006;20(1):45-56.
  > View abstract
HTLV
- Jauvin V, Alfonso RD, Guillemain B et al. In vitro photochemical inactivation of cell-associated human T-cell leukemia virus Type I and II in human platelet concentrates and plasma by use of amotosalen. Transfusion 2005;45(7):1151-9.
  > View abstract

Bruchmuller I, Janetzko K, Bugert P et al. Polymerase chain reaction inhibition assay documenting the amotosalen-based photochemical pathogen inactivation process of platelet concentrates. Transfusion 2005;45(9):1464-72.
> View abstract
Corash L, Stassinopoulos A. Is the SCID mouse model applicable to human acute lung injury? Transfusion In Press.

Bacteria

Brecher ME, Hay S, Corash L et al. Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatment. Transfusion 2007;47(10):1896-1901.
> View abstract
Jimenez-Marco T, Girona-Llobera E, Ruiz-Veramendi M et al. Usefulness of platelet (PLT) pathogen inactivation technology: a case of Sphingomonas paucimobilis inactivation in an apheresis PLT unit_2805. Transfusion 2010;50:2503-04.
> View Transfusion citation
Lin L, Dikeman R, Molini B et al. Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. Transfusion 2004;44(10):1496-504.
> View abstract

Leukocytes

Fiebig E, Hirschkorn DF, Maino VC et al. Assessment of donor T-cell function in cellular blood components by the CD69 induction assay: effects of storage, gamma radiation, and photo-chemical treatment. Transfusion 2000;40(7)761-70.
> View abstract
Grass JA, Hei DJ, Metchette K et al. Inactivation of leukocytes in platelet concentrates by photo-chemical treatment with psoralen plus UVA. Blood 1998:91(6):2180-8.
> View abstract
Grass JA, Wafa T, Reames A et al. Prevention of transfusion-associated graft-versus-host disease by photochemical treatment. Blood 1999;93(9):3140-7.
> View abstract
Hei DJ, Grass J, Lin L et al. Elimination of cytokine production in stored platelet concentrate aliquots by photochemical treatment with psoralen plus ultraviolet A light. Transfusion 1999;39(3):239-48.
> View abstract

Multiple Pathogens

Cazenave JP. Inactivation des pathogens des concenters plaquettaires: experience francaise. Transfusion Clinique et Biologique (June 2011) doi:10.1016/j.tracli.2011.05.002
> View abstract

Parasites

Leishmania
- Eastman RT, Barrett LK, Dupuis K et al. Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation. Transfusion 2005;45(9):1459-63.
  > View abstract
T. Cruzi
- Castro E, Gironés N, Bueno JL et al. The efficacy of photochemical treatment with amotosalen HCl and UVA (INTERCEPTTM) for inactivation of Trypanosoma cruzi in pooled buffy-coat platelets. Transfusion 2007, 47(3):434-441.
  > View abstract

Viruses

CMV
- Jordan CT, Saakadze N, Newman JL et al. Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model. Transfusion 2004;44(8):1159-65.
  > View abstract
- Lin L. Inactivation of cytomegalovirus in platelet concentrates using Helinx technology. Semin Hematol 2001;38(4 Suppl 11):27-33.
  > View abstract
Multiple Viruses
- Lin L, Hanson CV, Alter HJ et al. Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light. Transfusion 2005;45(4):580-90.
  > View abstract
SARS
- Pinna D, Sampson-Johannes A, Clementi M et al. Amotosalen photochemical inactivation of severe acute respiratory syndrome coronavirus in human platelet concentrates. Transfus Med 2005;15(4):269-76.
  > View abstract
Parvovirus B19
- Sawyer L, Hanson C, Castro G et al. Inactivation of parvovirus B19 in human platelet concentrates by treatment with amotosalen and ultraviolet A illumination. Transfusion 2007;47(6):1062-1070.
  > View abstract
West Nile Virus
- Gallian P, Vignoli C, Dombey AM et al. Inactivation of a European strain of West Nile Virus in single-donor platelet concentrate using the INTERCEPT Blood System. Vox Sang 2006;91(4):345-7.
  > View abstract

Viruses

Parvovirus B19
- Allain JP, Hsu J, Pranmeth M et al. Quantification of viral inactivation by photochemical treatment with amotosalen and UVA light, using a novel polymerase chain reaction inhibition method with preamplication. J Infect Dis 2006;194(12):1737-44.
  > View abstract