Inactivation

Platelets & Plasma

Parasites

  • Plasmodium & Babesia
    • P Grellier, J Benach, M Labaied, S Charneau, H Gil, G Monsalve, R Alfonso, L Sawyer, L Lin, M Steiert, K Dupuis.  Photochemical Inactivation with Amotosalen and Long-Wavelength Ultraviolet Light of Plasmodium and Babesia in Platelet and Plasma Components. Transfusion 2008;48(8):1676-84.
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  • T. Cruzi
    • Van Voorhis WC, Barrett LK, Eastman RT et al.  Trypanosoma cruzi inactivation in human platelet concentrates and plasma by a psoralen (amotosalen HCl) and long-wavelength UV.  Antimicrob Agents Chemother 2003;47(2):475-9.
      > View abstract

Viruses

  • CMV
    • Roback JD, Conlan M, Drew WL et al.  The role of photochemical treatment with amotosalen and UVA light in the prevention of transfusion-transmitted cytomegalovirus infections. Transfus Med Rev 2006;20(1):45-56.
      > View abstract
  • HTLV
    • Jauvin V, Alfonso RD, Guillemain B et al.  In vitro photochemical inactivation of cell-associated human T-cell leukemia virus Type I and II in human platelet concentrates and plasma by use of amotosalen. Transfusion 2005;45(7):1151-9.
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Platelets

  • Bruchmuller I, Janetzko K, Bugert P et al.  Polymerase chain reaction inhibition assay documenting the amotosalen-based photochemical pathogen inactivation process of platelet concentrates. Transfusion 2005;45(9):1464-72.
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  • Corash L, Stassinopoulos A.  Is the SCID mouse model applicable to human acute lung injury?  Transfusion In Press.

Bacteria

  • Brecher ME, Hay S, Corash L et al.  Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatment. Transfusion 2007;47(10):1896-1901.
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  • Jimenez-Marco T, Girona-Llobera E, Ruiz-Veramendi M et al.  Usefulness of platelet (PLT) pathogen inactivation technology: a case of Sphingomonas paucimobilis inactivation in an apheresis PLT unit_2805. Transfusion 2010;50:2503-04.
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  • Lin L, Dikeman R, Molini B et al.  Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. Transfusion 2004;44(10):1496-504.
    > View abstract

Leukocytes

  • Fiebig E, Hirschkorn DF, Maino VC et al. Assessment of donor T-cell function in cellular blood components by the CD69 induction assay: effects of storage, gamma radiation, and photo-chemical treatment.  Transfusion 2000;40(7)761-70.
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  • Grass JA, Hei DJ, Metchette K et al.  Inactivation of leukocytes in platelet concentrates by photo-chemical treatment with psoralen plus UVA. Blood 1998:91(6):2180-8.
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  • Grass JA, Wafa T, Reames A et al.  Prevention of transfusion-associated graft-versus-host disease by photochemical treatment.  Blood 1999;93(9):3140-7.
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  • Hei DJ, Grass J, Lin L et al.  Elimination of cytokine production in stored platelet concentrate aliquots by photochemical treatment with psoralen plus ultraviolet A light. Transfusion 1999;39(3):239-48.
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Multiple Pathogens

  • Cazenave JP.  Inactivation des pathogens des concenters plaquettaires:  experience francaise.  Transfusion Clinique et Biologique (June 2011) doi:10.1016/j.tracli.2011.05.002
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Parasites

  • Leishmania
    • Eastman RT, Barrett LK, Dupuis K et al.  Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation. Transfusion 2005;45(9):1459-63.
      > View abstract
  • T. Cruzi
    • Castro E, Gironés N, Bueno JL et al.  The efficacy of photochemical treatment with amotosalen HCl and UVA (INTERCEPTTM) for inactivation of Trypanosoma cruzi in pooled buffy-coat platelets. Transfusion 2007, 47(3):434-441.
      > View abstract

Viruses

  • CMV
    • Jordan CT, Saakadze N, Newman JL et al.  Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model. Transfusion 2004;44(8):1159-65.
      > View abstract
       
    • Lin L.  Inactivation of cytomegalovirus in platelet concentrates using Helinx technology. Semin Hematol 2001;38(4 Suppl 11):27-33.
      > View abstract
  • Multiple Viruses
    • Lin L, Hanson CV, Alter HJ et al.  Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light. Transfusion 2005;45(4):580-90.
      > View abstract
  • SARS
    • Pinna D, Sampson-Johannes A, Clementi M et al.  Amotosalen photochemical inactivation of severe acute respiratory syndrome coronavirus in human platelet concentrates. Transfus Med 2005;15(4):269-76.
      > View abstract
  • Parvovirus B19
    • Sawyer L, Hanson C, Castro G et al.  Inactivation of parvovirus B19 in human platelet concentrates by treatment with amotosalen and ultraviolet A illumination. Transfusion 2007;47(6):1062-1070.
      > View abstract
  • West Nile Virus
    • Gallian P, Vignoli C, Dombey AM et al.  Inactivation of a European strain of West Nile Virus in single-donor platelet concentrate using the INTERCEPT Blood System. Vox Sang 2006;91(4):345-7.
      > View abstract

Plasma

Viruses

  • Parvovirus B19
    • Allain JP, Hsu J, Pranmeth M et al.  Quantification of viral inactivation by photochemical treatment with amotosalen and UVA light, using a novel polymerase chain reaction inhibition method with preamplication. J Infect Dis 2006;194(12):1737-44.
      > View abstract
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