In vitro Function

Effect of INTERCEPT Treatment on Functional Characteristics of Platelets

Apheresis Platelets

  • 5-Day Storage
    • Janetzko K, Corash L, Lin L et al.  In vitro function of double-dose platelets treated with the pathogen inactivation Helinx technology.  In: Holick MF, ed. Biologic Effects of Light 2001.  Boston, MA:  Kluwer Academic Publishers, 2002:313-23.
      > View abstract
       
    • Janetzko K, Klinger M, Mayaudon V et al.  Storage characteristics of split double-dose platelet concentrates derived from apheresis and treated with amotosalen hydrochloride and UVA light for pathogen inactivation.  Transfusion Medicine and Hemotherapy 2002;29(4):193-98.
      > View abstract
  • 7-Day Storage
    • Cognasse F, Osselaer J-C, Payrat JM et al.  Release of immune modulation factors from platelet concentrates during storage after photochemical pathogen inactivation treatment.  Transfusion 2008;48(5):809-813.
      > View abstract
  • 5-Day and 7-Day Storage
    • Cognasse F, Payrat JM, Corash L et al.  Platelet components associated with acute transfusion reations:  the role of platelet-derived soluble CD40 Ligand.  Blood 2008;112(12):4779-4780.
      > View abstract

Buffy Coat-Derived Platelets

  • 5-Day Storage
    • Bruchmuller I, Losel R, Bugert P et al.  Effect of the psoralen-based photochemical pathogen inactivation on mitochondrial DNA in platelets.  Platelets 2005;16(8):441-5.
      > View abstract
  • 7-Day Storage
    • Lozano M, Galan A, Mazzara R et al.  Leukoreduced buffy coat-derived platelet concentrates photochemically treated with amotosalen HCI and ultraviolet A light stored up to 7 days: assessment of hemostatic function under flow conditions.  Transfusion 2007;47(4):666-71.
      > View abstract
       
    • Knutson F, Alfonso R, Dupuis K et al.  Photochemical inactivation of bacteria and HIV in buffy-coat-derived platetlet concentrates under conditions that preserve in vitro platelet function.  Vox Sang 2000;78(4):209-16.
      > View abstract
       
    • Picker SM, Speer R, Gathof BS.  Functional characteristics of buffy-coat PLTs photochemically treated platelet concentrates derived from buffy coats.  Vox Sang 2000;79(4):206-14.
      > View abstract
       
    • van Rhenen DJ, Vermeij J, Mayaudon V et al.  Functional characteristics of S-59 photochemically treated platelet concentrates derived from buffy coats.  Vox Sang 2000;79(4):206-14.
      > View abstract

Platelet-Rich Plasma (PRP)-Derived Platelets

  • 5-Day & 7-Day Storage Comparison
    • Wagner SJ, Skripchenko A, Myrup A et al.  Evaluation of in vitro storage properties of pre-storage  pooled whole blood derived platelets suspended in 100% plasma and treated with amotosalen and UVA light.  Transfusion 2009;49(4):704-10.
      > View abstract

Apheresis & Pooled Buffy Coat Platelets

  • Chavarin P, Cognasse F, Argaud C et al.  SHORT REPORT: In vitro assessment of apheresis and pool buffy coat platelet components suspended in plasma and SSP+ photochemically treated with amotosalen and UVA for pathogen inactivation (INTERCEPT Blood System).  Vox Sang 2011;100:247-249.
    > View abstract

Effect of INTERCEPT Treatment on Coagulation Factors of Plasma

Fresh Frozen Plasma (FFP)

  • Irsch J, Pinkoski L, Corash L et al.  INTERCEPT Plasma:  comparability to conventional FFP based on preservation of functionality and activation status – an in vitro analysis.  Vox Sang 2010;98(1):47-55.
    > View abstract
     
  • De Valensart N, Rapaille A, Goossenaerts E et al.  Study of coagulation function in thawed apheresis plasma for photochemical treatment by amotosalen and UVA.  Vox Sang 2009;96:213-18.
    > View abstract
     
  • Schlenke P, Hervig T, Isola H et al.  Photochemical treatment of plasma with amotosalen and UVA light:  process validation in three European blood centers.  Transfusion 2008:48(4):206-14.
    > View abstract

Cryosupernatant (CSP) Prepared from FFP

  • Yarranton H, Lawrie AS, Mackie IJ et al.  Coagulation factor levels in cryosupernatant prepared from plasma treated with amotosalen hydrochloride (S-59) and ultraviolet A light.  Transfusion 2005;45(9):1453-8.
    > View abstract
Untitled Document