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INTERCEPT Blood System for Platelets -
Pathogen Inactivation Data: Viruses

The INTERCEPT Blood System for platelets has been shown to inactivate a variety of viruses. Of viruses tested to date, only HAV and PPV were resistant to inactivation. The results of these studies are summarized below.

Viruses Tested Using the INTERCEPT Blood System for Platelets
Extent of Inactivation* (log10 reduction)
Platelets in plasma/additive solution
Platelets in plasma
Enveloped Viruses
HIV-1 (cell-associated)***
>6.1
>6.7
HIV-1 (cell-free)
>6.2
≥4.7
Clinical isolate of HIV-1
>3.4
-
Clinical isolate of HIV-2
>2.5
-
Latent proviral HIV-1
Inactivated to the limit of detection
-
HBV (strain MS-2)
>5.5
>4.5
HCV (strain Hutchison)
>4.5
>4.5
HTLV-I (Human T-cell Lymphotropic Virus)***
4.7**
≥4.5
HTLV-II (Human T-cell Lymphotropic Virus)***
5.1**
>5.7
Cell-associated Cytomegalovirus (CMV)***
>5.9
-
Bovine Viral Diarrhea Virus (BVDV, model virus for human HCV)
­>6.0
≥5.4
Duck Hepatitis B Virus (DHBV, model virus for human HBV)
>6.2
4.4 to 4.5
PRV (Pseudorabies virus, model for CMV)
-
≥4.7
West Nile virus
>6.0
≥6.8
SARS-CoV (Human Corona virus)
-
≥5.5
Chikungunya virus
>6.4
≥7.6
Influenza A H5N1 virus (Avian Influenza)
>5.9
>5.7
Non-Enveloped Viruses 
Bluetongue Virus, type 11
>5.0
5.1
Calicivirus
1.7 to 2.4
-
Human Adenovirus-5
>5.9
≥6.9
Parvo (Parvovirus B19)
-
1.8
* “>” refers to inactivation below the limit of detection of the assay. In some cases assays have a very small dynamic range due to limits on attainable virus titers.
** inherent low-level background in non-infected indicator cells precludes “>” of HTLV
*** intracellular
“-” means not tested

 

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Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.

The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma. No pathogen inactivation system has been shown to inactivate all pathogens.

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