INTERCEPT Blood System for Platelets
Indications & Contraindications

Indications
INTERCEPT Platelets are indicated for transfusion support of patients requiring platelet transfusions according to clinical practice guidelines. Any thrombocytopenia resulting from disease, therapy, or injury can be treated with INTERCEPT Platelets. INTERCEPT treatment may be used as an alternative to gamma irradiation for prevention of transfusion-associated graft-versus-host disease (TA-GVHD). INTERCEPT Platelets are not clinically different from untreated platelets and are infused according to standard platelet infusion methods.

Contraindications
Use of INTERCEPT Platelets is contraindicated in patients with a history of allergic response to amotosalen or psoralens.

Notes to Physicians
Neonatal patients who require platelet transfusions during phototherapy for treatment of hyperbilirubinemia should be treated with phototherapy devices that do not emit light less than 425nm to avoid the theoretical potentiation of an interaction between UVA light and psoralen, which may result in erythema.

While laboratory studies of photochemical treatment processing with the INTERCEPT Blood System for platelets have shown a reduction in the levels of certain viruses, bacteria and parasites, no pathogen inactivation process has been shown to eliminate all pathogens. This pathogen inactivation process is designed as a closed system. Pathogen inactivation does not replace applicable standards that apply to processing in closed and open systems.

Technical Data Sheets section page 2 of 7