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INTERCEPT Blood System for Platelets -
Pathogen Inactivation Data: Bacteria

The INTERCEPT Blood System for platelets has been shown to inactivate a variety of bacteria in platelet components. Inactivation studies using a range of gram positive and gram negative pathogenic bacteria demonstrated inactivation of approximately 6 logs of organisms, with the exception of P. aeruginosa and B. cereus (including spores), which showed reductions of 4.5 and 3.6 logs, respectively. Bacterial spores are resistant to inactivation; however, spore-forming bacteria in the vegetative state are sensitive to inactivation.
The results of these studies are summarized below:

Bacterial Species Tested Using the INTERCEPT Blood System for Platelets
Extent of Inactivation*
(log10 reduction)
 Platelets in plasma/Additive Solution
Platelets in plasma
Gram-Negative Bacteria
Escherichia coli
>6.4
≥7.3
Serratia marcescens
>6.7
-
Klebsiella pneumoniae
>5.6
≥6.7
Pseudomonas aeruginosa
4.5
-
Salmonella choleraesuis
>6.2
-
Yersinia enterocolitica
>5.9
>7.3
Enterobacter cloacae
5.9
-
Anaplasma phagocytophilum (HGE agent)**
-
>4.2
Gram-Positive Bacteria 
Staphylococcus epidermidis
>6.6
>7.4
Staphylococcus aureus
6.6
>7.6
Streptococcus pyogenes
>6.8
-
Listeria monocytogenes
>6.3
-
Corynebacterium minutissimum
>6.3
-
Bacillus cereus (includes spores)
3.6
-
Bacillus cereus (vegetative)
>6.0
-
Bifidobacterium adolescentis
>6.5
-
Propionibacterium acnes
>6.7
-
Lactobacillus species
>6.9
-
Clostridium perfringens (vegetative form)
>7.0
-
Spirochete Bacteria
Treponema pallidum (syphilis)
≥6.8 to ≤7.0
>5.9
Borrelia burgdorferi (Lyme disease)
>6.8
>10.6

* “>” refers to inactivation below the limit of detection of the assay
** intracellular
“-” means not tested

 

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Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.

The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma. No pathogen inactivation system has been shown to inactivate all pathogens.

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