INTERCEPT Blood System for Platelets
Pathogen Inactivation Data: Bacteria
The INTERCEPT Blood System for platelets has been shown to inactivate a variety of bacteria in platelet products. Inactivation studies using a range of gram positive and gram negative pathogenic bacteria demonstrated inactivation of approximately 6 logs of organisms, with the exception of P. aeruginosa and B. cereus (including spores), which showed reductions of 4.5 and 3.6 logs, respectively. Bacterial spores are resistant to inactivation; however, spore-forming bacteria in the vegetative state are sensitive to inactivation. The results of these studies are summarized below:
| Bacterial Species Tested Using the INTERCEPT Blood System for Platelets | Extent of Inactivation* (log10 reduction) |
| Gram-Negative Bacteria | |
| Escherichia coli | >6.4 |
| Serratia marcescens | >6.7 |
| Klebsiella pneumoniae | >5.6 |
| Pseudomonas aeruginosa | 4.5 |
| Salmonella choleraesuis | >6.2 |
| Yersinia enterocolitica | >5.9 |
| Enterobacter cloacae | 5.9 |
| Gram-Positive Bacteria | |
| Staphylococcus epidermidis | >6.6 |
| Staphylococcus aureus | 6.6 |
| Streptococcus pyogenes | >6.8 |
| Listeria monocytogenes | >6.3 |
| Corynebacterium minutissimum | >6.3 |
| Bacillus cereus (includes spores) | 3.6 |
| Bacillus cereus (vegetative) | >6.0 |
| Bifidobacterium adolescentis | >6.5 |
| Propionibacterium acnes | >6.7 |
| Lactobacillus species | >6.9 |
| Clostridium perfringens (vegetative form) | >7.0 |
| Spirochete Bacteria | |
| Treponema pallidum | ≥6.8 to ≤7.0 |
| Borrelia burgdorferi | >6.8 |
| * “>” refers to inactivation below the limit of detection of the assay | |
Technical Data Sheets section page 4 of 7 
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Cerus Corporation. All Rights Reserved.
Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.
The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma.
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Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.
The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma.
Website design by NetPilot Web Solutions