• Eliminated plasma quarantine, resulting in a 10-fold increase in plasma inventory

  • Eliminated gamma irradiation for prevention of TA-GvHD

  • Eliminated CMV serology

  • Avoided bacterial detection

  • Realized cost savings by optimizing buffy coat to apheresis platelet ratio

  • Reduced transfusion reactions

Collection Platform:
MCS+ (Haemonetics)

Platelet Suspension Medium:
PAS - InterSol (Fenwal)

INTERCEPT Disposable Set:
Large Volume, INT2202B

Separation Platform:
Manual – 6 BC
TACSI (Terumo) – 5 BC

Platelet Suspension Medium:
PAS - InterSol (Fenwal)

INTERCEPT Disposable Set:
Large Volume, INT2202B

Collection Platform:
MCS + (Haemonetics)

NTERCEPT Disposable Set:
INT3102B

 

Customer Profile: Etablissement Français du Sang – Alsace (EFS Alsace)

Date of INTERCEPT Implementation
2006: Apheresis & Buffy Coat Platelets
2007: Plasma

Annual Collections

• 120,000 whole blood donations
• 20,000 apheresis donations


Annual INTERCEPT Production
• 17,000 units of platelet concentrates
• 18,000 units of plasma (200mL each)

 


Production Profile
The Etablissement Français du Sang (EFS) Alsace in Strasbourg provides blood components for public hospitals and private clinics for a region of approximately 2 million people in eastern France. EFS Alsace maximizes organizational efficiency by leveraging a single approved system to inactivate pathogens in both platelet and plasma components with the INTERCEPT Blood System™. Adoption of INTERCEPT allowed EFS Alsace to optimize its ratio of buffy coat to apheresis platelet production, thus realizing cost savings for the organization. The system was implemented without modification to employee work hours or delay to component availability.

Production Lab
INTERCEPT processing at EFS Alsace requires less than 20m2.  Four illuminators provide the center with flexibility to treat 100% of their platelet and plasma collections.  Locating the INTERCEPT treatment area proximate to the platelet preparation room maximizes the center’s efficiency.

INTERCEPT Workflow
As depicted below, EFS Alsace has leveraged the wide processing parameters of INTERCEPT to develop a workflow that best meets their production demands and personnel work schedules.  Furthermore, the center’s introduction of INTERCEPT plasma eliminated the need for quarantine plasma which has resulted in a 10-fold increase in plasma inventory and increased their production flexibility.

INTERCEPT QC Results
Beginning in 2006 when they introduced INTERCEPT, EFS Alsace has maintained a rigorous QC program in order to ensure the final blood product characteristics are in compliance with national requirements.  The tables below include Alsace’s QC data for INTERCEPT treated apheresis platelets, buffy coat platelets, and apheresis plasma.  The buffy coat platelet data (Table 2) includes results from both manually prepared buffy coats (pools of 6) and those prepared with the TACSI system (pools of 5). 

Table 1: EFS Alsace QC Results for INTERCEPT Platelets - Apheresis
Parameter
INTERCEPT Platelets
(Average ± SD)
N
Volume (mL)
336 ± 22
19,248
Platelet count (x1011 plt/unit)
3.9 ± 0.8
19,248
pH (day 1)
7.2 ± 0.1
749
Post-CAD residual amotosalen (μM)a
0.55 ± 0.43
217
a. Nominal treatment concentration prior to illumination is 150 μM.

Table 2: EFS Alsace QC Results for INTERCEPT Platelets - Buffy Coat
Parameter
Manual BC Preparation
TACSI
INTERCEPT (Average ± SD)
N
INTERCEPT (Average ± SD)
N
Volume (mL)
313 ± 20
23,187
303 ± 16
11,146
Platelet count (x1011 plt/unit)
4.6 ± 0.7
23,187
4.0 ± 0.7
11,146
pH (day 2)
7.2 ± 0.1
315
7.2 ± 0.1
159
Post-CAD residual amotosalen (μM)a
0.29 ± 0.07
215
0.29 ± 0.05
89
a. Nominal treatment concentration prior to illumination is 150 μM.

Table 3: EFS Alsace QC Results for INTERCEPT Plasmaa
Parameter
INTERCEPT Platelets
(Average ± SD)
N
Volume (mL)
204 ± 8
39,026
Factor VIII (IU /mL)
0.8 ± 0.1
54
(pool of 6 plasma units)
Post-CAD residual amotosalen (μM)b
0.66 ± 0.1
171
a. N=14,977 INTERCEPT treatments with average input volume of 644 ± 5 mL; each treatment yields up to three final plasma units.
b. Nominal treatment concentration prior to illumination is 150 μM.