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INTERCEPT Blood System for Plasma - Because plasma is frozen under conditions that do not promote preservation of intact cells, TA-GVHD caused by leukocytes is of significantly less concern in frozen plasma than in other blood components. However, T-cells may retain functionality after freezing and TA-GVHD has been reported to result from transfusions of conventional plasma not treated with gamma irradiation. Two assays were used to evaluate inactivation of leukocytes: frequency of adduct formation in leukocyte DNA and limiting dilution assay to detect clonal expansion of viable T-cells. The results of these studies in plasma indicate effective inactivation of T-cells and leukocytes (see table below). The adduct frequency demonstrated is sufficient to ensure inactivation of most individual genes.
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Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.
The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma. No pathogen inactivation system has been shown to inactivate all pathogens.
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