INTERCEPT Blood System for Plasma
Pathogen Inactivation Data: Bacteria
Although bacterial contamination is not common for plasma, studies performed using representative gram-negative and gram-positive organisms demonstrated efficacy of the INTERCEPT process for bacterial inactivation. In addition, studies demonstrated inactivation of two spirochete bacteria, Treponema pallidum, for which blood is currently tested, and Borrelia burgdorferi. Studies were carried out with these organisms because they are known to be asymptomatically present in the blood during chronic infections. Bacteria, which have been shown to be inactivated, are listed below:
| Bacterial Species Tested Using the INTERCEPT Blood System for Plasma | Extent of Inactivation* (log10 reduction) |
| Gram-Negative Bacteria | |
| Klebsiella pneumoniae | ≥7.4 |
| Yersinia enterocolitica | >7.3 |
| Gram-Positive Bacteria | |
| Staphylococcus epidermidis | >7.3 |
| Spirochete Bacteria | |
| Treponema pallidum (syphilis) ** | >5.9 |
| Borrelia burgdorferi (Lyme disease) | >10.6 |
| * “>” refers to inactivation below the limit of detection of the assay; “≥” refers to inactivation at or below the limit of detection of the assay ** intracellular inoculum |
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Technical
Data Sheets section page 4 of 7 
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Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.
The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma.
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Use of the INTERCEPT Blood System in the United States is limited by Federal law to investigational use. If you are a resident of the U.S., please click here.
The information on this site is not country-specific, and may contain information that is outside the approved indications for the country in which you are located. The INTERCEPT Blood System is CE marked for use with platelets and plasma.
Website design by NetPilot Web Solutions